Primary Ovarian Carcinosarcoma: Cytological, Pathological, Immunocytochemical, and Immunohistochemical Features

Ovarian carcinosarcoma composed of high-grade carcinoma and sarcoma is an extremely rare neoplasm typically occurs in postmenopausal women aged over 60 years. A 73-year-old female, gravida three para three, presented to our hospital with right lower abdominal pain. Right pelvic solid tumor ascites was detected on ultrasound examination. She underwent hysterectomy, bilateral salpingo-oophorectomy partial omentectomy, but the had invaded ureter, some fragile could not be taken (sub-optimal surgery). On imprint ascitic cytology specimens during operation, atypical cells suggestive adenocarcinoma spindle immunocytochemically vimentin positive were found. The resected histopathologically consisted serous adenocarcinoma, chondrosarcoma fibrosarcoma. Immunohistochemical analysis revealed that for AE1/AE3 fibrosarcoma stained vimentin. final diagnosis ovarian (stage pT3CNxMx). Microsatellite instability stable BRCA1/2 mutations found cells. patient given four cycles chemotherapy paclitaxel, carboplatin bevacizumab regimen, thereafter she treated ifosfamide cisplatin because slight elevation serum CA125.